Quantitative Tracer Kinetic Analysis

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Once you are in the DCE Calculations tab, you are ready to analyze your DCE-CT/MR perfusion study.  The DCE Tool currently has the capability to analyze perfusion studies using the Standard Tofts Model and the Modified Tofts Model.  In addition, The DCE Tool provides a semi-quantitative analysis of your ROIs by default.  

  1. Select your arterial input function from the Arterial Input Function drop down menu.
  2. Select the tissue/tumor ROIs that you want to analyze from the Tissue Curve(s) table.
  3. You can select more than one tissues/ROIs by clicking the ROIs that you wish to select.
  4. To undo the selection of a ROI, simply click on the ROI that you do not wish to analyze in the Tissue Curve(s) table.
  5. Select the tracer kinetic model that you want to use for analysis from the Kinetic Model drop down menu.
  6. Verify or change the time interval you want to use to calculate the IAUC (Initial Area Under Curve).
  7. Verify or change the time interval you want to use to calculate the Initial Slope.
  8. Enter the correct Hematocrit Value (HCT).
  9. For DCE-CT, you will need to enter the onset time of contrast enhancement into the Onset Time table.
  10. For DCE-CT, you will also need to verify or change the time length you want to use.
  11. You can enter the number of Fitting Iterations by checking the box and changing the value.  However, this is not required.
  12. Click ROI(s) Analysis to proceed.

Your measured contrast enhancement-time curve(s) and the model-fitted contrast enhancement-time curve(s) are plotted on the screen.  You can visualize more than one ROI by selecting multiple ROIs that you want to see in the Curve Display table.  The tracer kinetic parameters derived from the model that you selected are also displayed on the screen.  You can go back to the previous DCE Settings sub-tab to analyze the same dataset using another model.